Fungal Infections

Species/common name:

Candida glabrata (older name: Torulopsis glabrata)

Teleomorph: None

Natural habitat

It is a saprophyte of the human being. It has also been found in baker´s yeast, excreta of cossidae larvae, birch wood, orange and passion fruit juice.

Geography

Worldwide.

Frequency

Depending on the geographical localization, C. glabrata is the second commonest cause of mucosal candidiasis (especially recurrent Candida vagnitis after multiple azole treatments) and a frequent cause of candidaemia and invasive yeast infections.

Diseases

It is the second most common cause of vaginitis. It is frequently isolated in cases of oropharyngeal and oesophageal candidiasis in AIDS patients, candidemia and urinary tract infections. It is also able to produce deep and disseminated infections especially in immunosupressed patients. Produce biofilms.

Culture peculiarities

The colonies in culture media are cream coloured. The appearance is soft and smooth and the surface is glossy. C. glabrata does not produce hypha or pseudohypha or chamydospores. It reproduces by means of budding.

Antifungal resistance (intrinsic and acquired)

Most strains are susceptible to amphotericin B, flucytosine and echinocandins. C. glabrata easily develops secondary resistance to azole drugs especially to fluconazole so this group of antifungals should be avoided in the treatment of infections caused by this microorganism. One exception may be urinary tract infections when fluconazole is highly concentrated in urine.

Biosafety level 2

This fungal species may be managed in a laboratory with safety containment level 2.

Industrial use

It has been used as a biosurfactant agent.

Review article on Candida glabrata

Images

Microscopic image

CHROMAgar™ image of Candida glabrata

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