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Fungal Infections

Species/common name:

Lichtheimia corymbifera
(syn. Mycocladus corymbifer, Absidia corymbifera)

Natural habitat

Most common in soil and decaying plant debris and foodstuffs.

Geography

Worldwide distribution.

Frequency

Like other Zygomycetes, frequency of infection is more common with immunocompromised hosts. However, it is becoming increasingly common in individuals without predisposing factors (e.g. in traumatic injuries).

Diseases

This fungus is one of only a few Mucormycotina that can cause disease in humans and animals.

Humans: Associated with cutaneous, pulmonary, rhinocerebral, central nervous system and disseminated infections.

Animals: Often associated with mycotic abortion.

Culture peculiarities

Great expertise required to differentiate from L. corymbifera. It is advisable to identify it by means of sequencing ITS fragment. Fast growing; pale white turning grey with age. Microscopically, sporangiospores mostly subspherical to broadly ellipsoidal. Slower growth than L. ramosa especially at higher temperatures.

Antifungal resistance (intrinsic and acquired)

All isolates are intrinsically resistant to fluconazole, ketoconazole, voriconazole and the echinocandins. Usually susceptible to amphotericin B and posaconazole. Variably susceptible to itraconazole.

Biosafety level

This organism can be handled in a biosafety level 2 laboratory.

Industrial use

Used in some studies of thermophilic moulds.

Images


Microscopic morphology of L. corymbifera.

Macroscopic morphology of L. corymbifera.

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