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New prospective open-label study on anidulafungin for invasive candidiasis in children

February 27 2019

IDSA guidelines for invasive candidiasis recommend first-line treatment with an echinocandin as these are fungicidal against most Candida spp. However, recommendations for children are largely extrapolated from adult trials.

Dr Emmanuel Roilides and colleagues1 recently published an open-label study of anidulafungin in 49 children (aged 2-18 years) with culture-confirmed invasive candidiasis. Patients received a loading dose of 3mg/kg on day 1, followed by 1.5mg/kg maintenance dose for a further 10-35 days.

  • The success rate of treatment (71%) was similar to that previously reported for adults (~75%), although this study was not powered to judge efficacy.
  • All patients reported at least one adverse event4, with the most common being diarrhoea (22%), vomiting (25%) or pyrexia (18%). However, only around 1/3 (37%) of these were judged by investigators to be possibly related to the treatment.
  • Around half of the patients (51%) switched to fluconazole, and 10% discontinued due to AEs.
  • Around 2/3 of patients (65%) had central venous catheter involvement. IDSA recommend removing a catheter as soon as possible where this is thought to be the site of infection.

Read the article: Roilides et al (2019) Ped Infect Dis J 28(3): 275-9

Read reviews on paediatric use of anidulafungin, caspofungin, or micafungin for invasive candidiasis.

 

 

 

Caspofungin

Micafungin

Anidulafungin

Studies

Zaoutis et al, 2009 3

n = 38

Prospective open-label

Benjamin et al, 2018 2

n = 20

Randomised controlled trial

Roilides et al, 2019 1

N = 49

Prospective open-label

Efficacy/response

81%

Complete or partial response

60%

Fungal-free survival

71%

Global response

Patients reporting possibly drug-related adverse events

Clinical (24%)

Laboratory (40%)

55%

37%

Serious drug-related adverse events

0

Not reported

1

Discontinuation due to adverse events

0%

15%

10%

Most common adverse events

Fever, rash, raised ALT/AST, hypokalaemia

Anaemia, thrombocytopaenia

Diarrhoea, vomiting, pyrexia

N = number of patients with invasive candidiasis who received that echinocandin

 

Picture from chrisjohnsonmd.com

 

1 The study was supported and co-authored by Pfizer, who produce anidulafungin under the brand name Eraxis/Ecalta. Read more at their website

2 This study was supported and co-authored by Astellas Pharma Inc

3 This study was supported and co-authored by Merck

4 Here ‘adverse event’ means a symptom that begins after initiation of anidulafungin treatment. It does not necessarily mean that the antifungal caused the symptom