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Less than $1000 to save a life from cryptococcal meningitis with flucytosine

December 20 2019

Data from the ACTA trial suggests that 14 days of dual therapy (fluconazole+flucytosine) reduces mortality from 54% to 35% in the first 10 weeks. The cost of treating all patients worldwide would be around $40,604,200 per year - equivalent to only $973 per life saved.
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Update of the EORTC Consensus Definitions of Invasive Fungal Disease

December 09 2019

The EORTC consensus definitions of invasive fungal infections have now been updated to include new patient groups (e.g. children and those taking ibrutinib) and diseases (e.g. Pneumocystis, endemic mycoses), and to reflect recent progress in diagnostics including Aspergillus/Candida PCR and galactomannan
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Diagnosis of tinea capitis in adults is challenging

December 09 2019

Tinea capitis is uncommon in adults, and often initially misdiagnosed as bacterial folliculitis, allergic contact dermatitis, psoriasis or eczema
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NICU fluconazole prophylaxis may lead to Malassezia colonisation and fungaemia

October 17 2019

IDSA recommends fluconazole prophylaxis for the first six weeks in premature neonates weighing <1kg in units with high rates (>10%) of invasive candidiasis. Dr Chen and colleagues in Taiwan found that introducing fluconazole prophylaxis reduced cases of candidaemia from 1-2 cases per year (per ~780 patients) to zero. However, Malassezia colonisation and fungaemia rose during this time.
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Fungal infection burdens presented at TIMM: Morocco, Sudan, Cote d’Ivoire, Tajikistan, Azerbaijan

October 14 2019

Estimates of the incidence and prevalence of fungal infections were presented this week at TIMM2019 (Nice, France) for a further 5 countries: Morocco, Sudan, Cote d’Ivoire, Tajikistan and Azerbaijan.
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