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Multi-country burden of fungal disease presented at ECCMID conference

April 29 2013

Multi-country burden of fungal disease presented at ECCMID conference

The number of people suffering and dying from fungal infections has been estimated in 12 countries in which 3.1 billion people live, 45% of the world’s population. Posters presented at the ECCMID meeting in Berlin revealed especially high incidence rates of Candida bloodstream infection in Brazil (15/100,000) and Spain (10.7/100,000), an extremely high rate of mucormycosis in India (170,000 cases annually, 13/100,000) related to the burgeoning epidemic of diabetes there, over 160,000 cases of invasive aspergillosis in China (11.9/100,000), over 2,783 cases of cryptococcal meningitis in AIDS in Uganda (8/100,000, 75% mortality) and 75,000 and 18,000 cases of Pneumocystis pneumonia in Nigeria (48/100,000) and Brazil (39.6/100,000) respectively.  

Even more prevalent were allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization (SAFS) complicating asthma. For example, an estimated 390,000 ABPA cases were estimated for Brazil (201/100,000), 491,000 cases for China (36.1/100,000) and at least 592,000 ABPA cases in India (47/100,000).  The prevalence of SAFS was estimated to be higher, but has yet to be studied epidemiologically. Estimates of tinea capitis were very high in Africa, notably 15,580,000 cases in Nigeria (~50% of 155 million population are children) (1000/100,000) and 1,700,000 children affected in Kenya (4,300/110,000).

More prevalent still, was recurrent Candida vaginitis (vulvovaginal candidiasis) in which the estimated prevalence rate in 15 to 50 year old women varied from 874 (Spain) to 3,800 (Nigeria) per 100,000 females. View slides "Global epidemiology of fungal infections. Sevtap Arikan".

The original abstracts can be viewed here.

The posters can be viewed here : Austria, Brazil, China, India (ABPA, SAFS and CPA), India (mucormycosis), Ireland, Israel, Kenya, Netherlands, Nigeria, Senegal, Singapore, Spain, Uganda.
Professor Arnaldo Colombo making a point about the high frequency of fungal infections in Brazil to Dr Alessandro Passqualoto and Dr Flavio Queiroz-Telles.

All the estimates were based on modeling, supported by all epidemiological studies from each country. Insufficient epidemiological studies have been conducted in each country to confirm the estimates with confidence, but estimates were generally conservative. The general approach to this modelling is described on the Fungal Infection Trust  website, although a novel approach was used to estimate mucormycosis cases in India.

ECCMID is Europe’s premier infectious disease conference with ~10,000 attendees. Held annually it is a showcase for all microbiology and infectious diseases research across Europe and the world, as well as the burgeoning diagnostic industry in Europe. Hosted by the European Society for Clinical Microbiology and Infectious Diseases ESCMID all the abstracts are published in the Society’s journal - Clinical Microbiology and Infection.

Publications: Burden of Disease in Israel (2015)